iTRAQ4plex (N-term) iTRAQ4plex (K) iTRAQ4plex (Y) 0.0 1.0 5.9 0.2 0.0 2.0 5.6 0.1 0.0 3.0 4.5 0.1 0.1 4.0 3.5 0.0 iTRAQ_variable iTRAQ8plex (N-term) iTRAQ8plex (K) iTRAQ8plex (Y) 0.00 0.00 6.89 0.24 0.00 0.94 5.90 0.16 0.00 1.88 4.90 0.10 0.0 2.82 3.90 0.07 0.06 3.77 2.88 0.00 0.09 4.71 1.91 0.00 0.14 5.66 0.87 0.00 0.27 7.44 0.18 0.00 iTRAQ_variable TMT6plex (N-term) TMT6plex (K) TMT2plex (N-term) TMT2plex (K) Label:18O(1) (C-term) Label:18O(2) (C-term) 0.0 5.0 95.0 y y ICPL (K) ICPL:13C(6) (K) 0.0 0 100 ICPL (K) ICPL (N-term) ICPL:13C(6) (K) ICPL:13C(6) (N-term) 0.0 0 100 ICPL (K) ICPL:13C(6) (K) ICPL:2H(4) (K) 0.0 0 100 0 100 Label:18O(1) (C-term) Label:18O(2) (C-term) 0.0 1.0 99.0 Ag Au N 15N 99.0 1.0 Ag Au N 15N C 13C 99.0 1.0 99.0 1.0 Label:13C(6) (K) Label:13C(6)15N(4) (R) 0.0 1.0 99.0 1.0 99.0 Label:13C(6) (K) Label:13C(6)15N(4) (R) 0.0 1.0 99.0 1.0 99.0 satellite Label:13C(6) (K) Label:13C(6) (R) 0.0 0 100 Label:13C(6)15N(4) (R) 0.0 0 100 0 100 Label:13C(6) (R) Label:13C(6)15N(2) (K) Label:13C(6)15N(4) (R) 0.0 0 100 0 100 Label:2H(4) (K) Label:13C(6) (R) Label:13C(6)15N(2) (K) Label:13C(6)15N(4) (R) 0.0 0.0 100.0 0.0 100.0 0.0 100.0 ICAT-C (C) ICAT-C:13C(9) (C) 0.0 0 100 *[C] ICAT-D (C) ICAT-D:2H(8) (C) 0.0 0 100 *[C] Dimethyl (K) Dimethyl (N-term) Dimethyl:2H(4) (K) Dimethyl:2H(4) (N-term) Dimethyl:2H(6)13C(2) (K) Dimethyl:2H(6)13C(2) (N-term) 0.0 0 100 0 100 NBS (W) NBS:13C(6) (W) 0.0 0 100 *[W] 1 2 3