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We enjoyed speaking with many of you in Philadelphia last week at the ASMS Conference. We have a few new video presentations to showcase some of our latest developments.

This month's highlighted publication describes a new approach for 3D bioprinted tumor models. If you have a recent publication that you would like us to consider for an upcoming Newsletter, please send us a PDF or a URL.

Please have a read and feel free to contact us if you have any comments or questions.


November 2021

ASMS Presentations
Featured publication

ASMS 2021 presentations

We have four new presentations for ASMS this year that describe some of the latest tools and features that can help you improve and accelerate your searches. They are available as videos or as PDF's with dialog text.


New features in Mascot Server 2.8

  MP4 Narrated video

   PDF  PDF of slides and text


New features in Mascot Distiller 2.8

  MP4 Narrated video

   PDF  PDF of slides and text


Statistical significance in Error Tolerant search results

  MP4 Narrated video

   PDF  PDF of slides and text


LFQ for the masses

  MP4 Narrated video

   PDF  PDF of slides and text

ASMS 2021

Featured publication using Mascot

Here we highlight a recent interesting and important publication that employs Mascot for protein identification, quantitation, or characterization. If you would like one of your papers highlighted here please send us a PDF or a URL.


Decellularized Extracellular Matrix Composite Hydrogel Bioinks for the Development of 3D Bioprinted Head and Neck in Vitro Tumor Models

Jacqueline Kort-Mascort, Guangyu Bao, Osama Elkashty, Salvador Flores-Torres, Jose G. Munguia-Lopez, Tao Jiang, Allen J. Ehrlicher, Luc Mongeau, Simon D. Tran, and Joseph M. Kinsella

ACS Biomater. Sci. Eng., online October 18, 2021

The common methods utilizing in vitro monolayer cell culture systems and preclinical in vivo small animal tumor xenografts can be deficient or introduce biological cues that are not present in native human tumors. To address this, the authors have sought to develop bioprintable materials for encapsulating tumor cells that have acceptable printability, cell proliferation, spheroid formation, and stiffness.

They prepared the bioink by decellularizing porcine tongue tissue (dECMT) and incorporating sodium alginate and gelatin at controlled weight percentages as rheological modifiers. LC-MS/MS of the dECMT found the proteins included different types of collagens, laminin, and glycosaminoglycans with collagens the most abundant structural proteins, accounting for more than 90% of the total ECM protein.

They characterized the mechanical and biochemical properties of the composite materials, and used them to encapsulate human head and neck squamous cell carcinoma cells. The bioprinted 3D structures allowed the cancer cells to develop into tumor spheroids over 19 days while maintaining high cell viability and supporting proliferation.

Dose-response experiments revealed increased IC50 values for both cisplatin and 5-fluorouracil cultured in these 3D models when compared to 2D conditions. The decrease in sensitivity observed in 3D cultures can be attributed to the non-physiological conditions that 2D cultures offer.

Thumbnail from featured publication

About Matrix Science

Matrix Science is a provider of bioinformatics tools to proteomics researchers and scientists, enabling the rapid, confident identification and quantitation of proteins. Mascot software products fully support data from mass spectrometry instruments made by Agilent, Bruker, Sciex, Shimadzu, Thermo Scientific, and Waters.

Please contact us or one of our marketing partners for more information on how you can power your proteomics with Mascot.


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Matrix Science Ltd, 64 Baker Street, London W1U 7GB, UK
T +44 (0)20 7486 1050  F +44 (0)20 7224 1344  E

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