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Welcome
Join us at ASMS 2026 in San Diego, CA from 31st May to 4th June.
This month's highlighted publication investigates the effect of uropein-based olive leaf extract on human skeletal muscle after cardiovascular exercise.
After ASMS, we're heading to BSPR 2026 and IMSC 2026.
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Mascot: The trusted reference standard for protein identification by mass spectrometry for 25 years
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Matrix Science at ASMS 2026
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Matrix Science is attending ASMS 2026 from 31st May to 4th June in San Diego, CA.
Please drop by booth #616 any time during the conference.
We have been working hard on finalising DIA support in Mascot.
At ASMS 2026, we are presenting three posters featuring Mascot DIA using real data.
Please visit our booth for a live demo.
WP 449: Mascot DIA introduces probabilistic scoring to spectrum-centric analysis of DIA data.
Presented by Ville Koskinen.
Wednesday 3rd June, Informatics: Peptide ID and Quantification.
WP 464: Mascot DIA enables direct comparison of DDA and DIA identification and quantitation results.
Presented by Patrick Emery.
Wednesday 3rd June, Informatics: Peptide ID and Quantification.
WP 622: Overcoming Peptide-Centric DIA Limitations: Discovering Unsuspected Modifications in Narrow-Window DIA Using Mascot Error Tolerant Search.
Presented by Richard Jacob.
Wednesday 3rd June, Peptides: PTM Identification
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Featured publication using Mascot
Here we highlight a recent interesting and important publication that employs Mascot for protein identification, quantitation, or characterization. If you would like one of your papers highlighted here, please send us a PDF or a URL.
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Uropein-based olive leaf extract enhances muscle mitochondrial bioenergetics response to moderate – but not maximal – intensity exercise in humans
Clément Lanfranchi, Alba Moreno-Asso, Astrid M. H. Horstman, Sara Mistro, Eugenia Migliavacca, Ornella Cominetti, Jens Stolte, Sylviane Métairon, Aurélie Hermant, Ane Laura Pedersen, Loïc Dayon, Umberto De Marchi, Jérôme N. Feige, Nadège Zanou, Nicolas Place
J Physiol, 604: 3802-3824 (2026), doi:10.1113/JP290316
Poor cardiorespiratory fitness is associated with several chronic diseases, many of which can be delayed or prevented by means of regular aerobic exercise.
Two effective exercise routines are moderate-intensity continuous exercise (MICE) and sprint interval exercise (SIE).
SIE has been shown to be equally or more effective than MICE despite a lower workload and shorter duration, which is partly due to differences in mitochondrial metabolism leading to pyruvate dehydrogenase (PDH) activation.
The authors hypothesised that administering natural polyphenol oleuropein from olive leaf extracts (OLEs) may activate PDH and potentiate mitochondrial adaptations.
They carried out a crossover, double-blind study where healthy participants completed MICE or SIE routines with either placebo or an OLE dietary supplement.
Muscle biopsies were collected before, immediately after, and 24 hours after exercise; samples from the placebo group were labelled with TMT-6plex.
Mascot Server 2.8 was used for peptide and protein identification, followed by downstream analysis in Scaffold Q+ 5.
Of 1497 proteins identified, MICE was shown to have modified the levels of 174 proteins immediately post exercise and 4 proteins after 24 hours.
SIE modified the levels of 15 proteins immediately post exercise and none after 24 hours.
The most upregulated pathways immediately after both MICE and SIE were immune and inflammatory responses, while mitochondrial-related pathways were somewhat down regulated – consistent with previously reported decrease in mitochondrial respiratory capacity after high-intensity exercise.
The effect of using OLE was then investigated using RNAseq.
This revealed effects on the mitochondrial and inflammatory response after MICE and SIE, but an increase in PDH activity only after MICE.
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BSPR 2026 and IMSC 2026
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After ASMS in June, we're travelling to Cambridge, UK for BSPR 2026 on 13-15th July.
Come chat with us about the latest developments with Mascot.
Conference registration ends on 22nd June, so do visit the BSPR registration portal soon.
In August, meet us in Lyon, France at IMSC 2026.
We'll be at booth #40 for the duration of the conference, 22nd-28th August.
Join us there and see a demo of the latest version of Mascot.
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About Matrix Science
Matrix Science is a provider of bioinformatics tools to proteomics researchers and scientists, enabling the rapid, confident identification and quantitation of proteins. Mascot continues to be cited by over 2000 publications every year. Our software products fully support data from mass spectrometry instruments made by Agilent, Bruker, Sciex, Shimadzu, Thermo Scientific, and Waters.
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You can also contact us or one of our marketing partners for more information on how you can power your proteomics with Mascot.
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