Mascot: The trusted reference standard for protein identification by mass spectrometry for 25 years

Licensing overview

You can buy Matrix Science products from a number of regional distributors and marketing partners. Alternatively, Get a quote by contacting us directly. Sales enquiries for all products may be directed to one of the Matrix Science offices listed on our Contact page.

Solution packages

Mascot DIA is a spectrum-centric approach for identifying and quantifying proteins from Data Independent Acquisition (DIA) runs.

Mascot DDA is a spectrum-centric approach for identifying and quantifying proteins from Data Dependent Acquisition (DDA) runs.

Mascot PMF is a high-throughput system for identifying proteins from Peptide Mass Fingerprinting (PMF) data.

The solutions are built on three products: Mascot Distiller (preprocessing and quantitation), Mascot Server (high-throughput identification) and Mascot Daemon (automation).

Mascot Distiller

Mascot Distiller is a vendor independent application for identifying and quantifying proteins using Mascot database searching. It offers a single, intuitive interface to native (“raw”) mass spectrometry data files for DIA, DDA and PMF analysis from Agilent, Bruker, SCIEX, Shimadzu, Thermo and Waters.

Mascot Distiller is licensed per workstation (PC). Multiple users can share a single installation by logging in to Windows as different users via Windows Remote Desktop or similar (requires a server edition of Windows).

The licence is perpetual, not an annual fee, and includes 1 year warranty covering technical support and all updates. After the first year, if you wish to continue receiving technical support and updates, you have the option of purchasing a support contract for 35% of the licence fee per year. Alternatively, you can buy a single version update for 50% of the licence fee.

To increase throughput, multiple Distiller clients running on separate PCs can use the same Mascot Server for database searching.

We recommend installing Distiller on a PC with fast multi-core processor(s), at least 32GB of RAM (preferably 64GB) and a few terabytes of fast storage (RAID or NVMe). When processing a multi-file project, Distiller can use all of the available processing capacity.

Mascot Server

Mascot Server is a powerful search engine for identifying proteins from mass spectrometry data. It is available for Microsoft Windows and Linux on Intel and AMD processors.

Entry level is a Small licence (8 cores/16 threads). There are no restrictions on the number of users submitting searches to the Mascot server or the size of the searches. If you require greater speed or throughput, you can upgrade to Medium (16 cores/32 threads) or Large tier (128 cores/256 threads).

If the system has more cores than are covered by the licence, the surplus cores are used for generating reports and web server/operating system overhead.

The licence is perpetual, not an annual fee, and includes 1 year warranty covering technical support and all updates. After the first year, if you wish to continue receiving technical support and updates, you have the option of purchasing a support contract for 35% of the licence fee per year. Alternatively, you can buy a single version update for 50% of the licence fee.

When choosing hardware, choose a system with an 8-16 core processor with high clock speed (4GHz or higher); at least 16GB RAM; maybe 1-2 TB of storage. NVMe storage speeds up data processing before and after a database search, but not during the database search. There are more detailed notes in PC hardware for Mascot Server.

Mascot Daemon

Mascot Daemon is a Microsoft Windows client application that automates raw file processing and Mascot database searching. When Mascot Distiller is used as the data import filter, Mascot Daemon automates all steps of protein identification and quantitation for DIA, DDA and PMF analysis.

Mascot Daemon is bundled with Mascot Server. It can be installed as required without additional licence fees.

Mascot ParserFree

Mascot Parser is a toolkit providing an object oriented interface to Mascot Server result files and Mascot Distiller project files. Mascot Parser makes it easy for programs written in C++, C#, Python, Java or Perl to access Mascot results. It is free for all purposes except redistribution as part of a commercial software package.