Mascot: The trusted reference standard for protein identification by mass spectrometry for 25 years

Free Trial: Evaluate Mascot Distiller

Mascot Distiller is a vendor independent application for identifying and quantifying proteins using Mascot database searching. It offers a single, intuitive interface to native (“raw”) mass spectrometry data files for DIA, DDA and PMF analysis.

A Distiller project file is also an ideal way to supply supporting data for a publication to a journal. Referees can use Distiller in free, viewer mode to drill down into every detail of peak lists, Mascot search results, and quantitation reports without needing access to the instrument data system or your in-house Mascot server.

System requirements

Mascot Distiller requires 64-bit Microsoft Windows 10 or later, Server 2016 or later. Distiller is fully compatible with Windows 11/Server 2022/Server 2025. In all cases, the latest service pack should be applied. Mascot Distiller requires .NET Framework 4.7 or later to run.

For the trial, we recommend an Intel Core i7 or AMD Ryzen 7 processor with at least 16 cores, 32GB RAM (preferably 64GB) and a fast disk. NVMe is recommended. Distiller does not use a GPU; all computation is done on the CPU.

Free 30-day trial

To obtain a free 30-day trial:

  1. Download the 64-bit installer (341 MB). Choose either to “Run this program from its current location” or “Save this program to disk”, then execute it. The installer is signed by Matrix Science Ltd.
  2. Obtain a free product key by sending an email request to support@matrixscience.com.
  3. Follow the instructions to register the free product key online to obtain a 30-day licence.

Mascot Distiller integrates with Mascot Server for protein identification by database searching. We recommend the latest release of Mascot Server. Batch automation of quantitation requires Mascot Daemon, which is shipped as part of Mascot Server.

For the free trial, you can either connect to an in-house Mascot Server installation or the free Mascot service running at matrixscience.com.

Permanent licence

After licence expiry, Mascot Distiller will run in viewer mode, allowing you to browse existing projects but not modify them or create new ones.

Get a quote for a permanent licence.

Mascot DIA

Mascot Distiller supports data independent acquisition (DIA) experiments using:

Support for Bruker diaPASEF is planned.

Mascot DDA and PMF

Mascot Distiller supports data dependent acquisition (DDA) and peptide mass fingerprint (PMF) experiments from all major instruments used in proteomics research today, including: