Mascot: The trusted reference standard for protein identification by mass spectrometry for 25 years

Mascot Daemon is the automation client included with Mascot Server. For Mascot 2.1 onwards, there are links to install and update Mascot Daemon on the home page of your local Mascot Server.

It is important to update Mascot Daemon whenever you update Mascot Server, so that the first two fields of the Mascot Daemon version number match those of the Mascot Server. The third field of the version number is the patch level, and this does not need to match, but it is advisable to use the latest patch level available.

The current release of Mascot Daemon is version 2.8.0

Known Issues

Transport Layer Security

If your Mascot Server URL begins https:, the connection is encrypted using either Secure Sockets Layer (SSL) or Transport Layer Security (TLS). All versions of SSL and versions 1.0 and 1.1 of TLS are now deprecated because of known security vulnerabilities. If these are disabled in your web server configuration, so that only TLS 1.2 (and possibly 1.3) are available, you may encounter problems with the connection between Mascot Daemon and Mascot Server.

Mascot Daemon is a .NET application. Enabling TLS 1.2 on the Mascot Daemon PC requires .NET framework 4.6 or later to be installed. It may also require a Windows update to be applied and changes to the Windows registry. For Windows Vista SP2 or Windows Server 2008 SP2 or later, the procedure to enable TLS 1.2 is described here.

Microsoft has very limited support for TLS 1.3. Status as of January 2020 is described here.