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Posted by Ville Koskinen (June 17, 2021)

NCBI nr tips

NCBI nr is the comprehensive database of non-identical protein sequences compiled by the National Center for Biotechnology Information. The database is available in Mascot Server as the NCBIprot predefined definition. If possible, nr should be used as the database of last resort due to its huge size. The January 2021 version contains 338 million protein sequences and the FASTA file [...]

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Posted by Richard Jacob (December 22, 2020)

How large a Mascot Server licence do I need?

One frequent question from new customers is how many CPUs do I need to licence for my Mascot Server? This is actually two questions. First, Mascot is licensed in CPU units, where 1 CPU is good for 4 cores. The computer can have more than one processor, and each processor can have more than 4 cores, but only the number [...]

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Posted by John Cottrell (September 18, 2018)

Mascot Server cluster mode

Most modern Intel processors have at least 4 cores and some models have 12 cores or more. Mascot Server is licenced by the CPU, where each CPU corresponds to 4 physical cores, so a single PC is perfectly sufficient for licences of 1 or 2 CPU. If you have a larger licence, there comes a point where it is not [...]

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Posted by Richard Jacob (September 14, 2016)

Getting the most out of your Mascot Server hardware

A Mascot Server search consists of a number of separate stages. Once the input file has been uploaded to the server, Mascot starts by sorting the peak list by peptide molecular mass. Unless the peak list is very small, it also divides the peak list into chunks limited in size by either the number of bytes or the number of [...]

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Posted by Richard Jacob (December 14, 2014)

Running Mascot Server on a supercomputer

A supercomputer comprises a large number of dedicated processors, typically hundreds to thousands, that are situated close together in racks and cabinets and connected by a fast network. An individual computational node might look like a normal server or may be a more specialized blade server or a bare bones system of the sort Google and Facebook sometimes use. Their [...]

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Posted by John Cottrell (January 20, 2014)

How long should a search take? – Hardware and configuration

This question comes up quite frequently. Sometimes in the form of "How large a licence do I need?" and sometimes as "My searches seem slower since I re-installed Mascot / updated to the new version / moved to new hardware." Resisting the temptation to reply "How long is a piece of string?", let’s review some of the factors that influence [...]

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Posted by Chris Allen (July 15, 2013)

Running Mascot in a virtual machine

One of the most significant trends in IT in recent years has been the shift towards virtual machines. Virtualisation can offer a host of advantages such as consolidation, elastic provisioning, high availability / disaster recovery, multi-tenant isolation, and legacy OS support. At Matrix Science for example, being able to run many different operating system configurations on a single PC makes [...]

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